{"id":19,"date":"2014-11-04T11:17:40","date_gmt":"2014-11-04T10:17:40","guid":{"rendered":"http:\/\/riviere.mketjh.fr\/?page_id=19"},"modified":"2016-02-12T20:40:22","modified_gmt":"2016-02-12T19:40:22","slug":"r-packages","status":"publish","type":"page","link":"https:\/\/riviere.mketjh.fr\/?page_id=19","title":{"rendered":"R packages"},"content":{"rendered":"<p>We have developped two R packages available on <a title=\"cran\" href=\"http:\/\/cran.r-project.org\/\" target=\"_blank\">CRAN<\/a>:<\/p>\n<ul>\n<li><a title=\"dfcomb\" href=\"http:\/\/cran.r-project.org\/web\/packages\/dfcomb\/index.html\" target=\"_blank\"><strong>dfcomb<\/strong><\/a> &#8211; for combination of molecules\n<ul>\n<li>for the combination of two agents where the toxicity (and efficacy) of both agent is assumed to increase with the dose (e.g. combination of two cytotoxic agents).<\/li>\n<li>for the combination\u00a0of two agents where the toxicity and effiacy are\u00a0assumed to increase with the dose but the efficacy of one agent may plateau from a certain dose level (e.g. combination of a cytotoxic with a molecularly targeted agent).<\/li>\n<\/ul>\n<\/li>\n<li><a title=\"dfmta\" href=\"http:\/\/cran.r-project.org\/web\/packages\/dfmta\/index.html\" target=\"_blank\"><strong>dfmta<\/strong><\/a> &#8211; for Molecularly Targeted Agent (MTA) in single-agent<\/li>\n<li><a title=\"MIXFIM\" href=\"https:\/\/cran.r-project.org\/web\/packages\/MIXFIM\/index.html\" target=\"_blank\"><strong>MIXFIM<\/strong><\/a> &#8211; for the evaluation of the Fisher information matrix in nonlinear mixed effect models using a Markov Chains Monte Carlo&#8217;s method<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>We have developped two R packages available on CRAN: dfcomb &#8211; for combination of molecules for the combination of two agents where the toxicity (and efficacy) of both agent is assumed to increase with the dose (e.g. combination of two cytotoxic agents). for the combination\u00a0of two agents where the toxicity and effiacy are\u00a0assumed to increase &hellip; <a href=\"https:\/\/riviere.mketjh.fr\/?page_id=19\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">R packages<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/riviere.mketjh.fr\/index.php?rest_route=\/wp\/v2\/pages\/19"}],"collection":[{"href":"https:\/\/riviere.mketjh.fr\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/riviere.mketjh.fr\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/riviere.mketjh.fr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/riviere.mketjh.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=19"}],"version-history":[{"count":6,"href":"https:\/\/riviere.mketjh.fr\/index.php?rest_route=\/wp\/v2\/pages\/19\/revisions"}],"predecessor-version":[{"id":84,"href":"https:\/\/riviere.mketjh.fr\/index.php?rest_route=\/wp\/v2\/pages\/19\/revisions\/84"}],"wp:attachment":[{"href":"https:\/\/riviere.mketjh.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=19"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}